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Article

Demonstrating polymorphic miRNA-mediated gene regulation in vivo: application to the g+6223G->A mutation of Texel sheep.

RNA (New York, N.Y.) - 1 Sept 2010

Takeda Haruko, Charlier Carole, Farnir Frédéric, Georges Michel

Abstract excerpt

We herein describe the development of a biochemical method to evaluate the effect of single nucleotide polymorphisms (SNPs) in target genes on their regulation by microRNAs in vivo. The method is based on the detection of allelic imbalance in RNAs coimmunoprecipitated with AGO proteins from tissues of heterozygous individuals. We characterize the performances of our approach using a model system in a cell...

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PMID: 20679369
DOI: 10.1261/rna.2131110
PMCID: PMC2924544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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