Article
Catalog of microRNA seed polymorphisms in vertebrates.
PloS one - 1 Jan 2012
Zorc Minja, Skok Dasa Jevsinek, Godnic Irena, Calin George Adrian, Horvat Simon, Jiang Zhihua, Dovc Peter, Kunej Tanja
Abstract excerpt
MicroRNAs (miRNAs) are a class of non-coding RNA that plays an important role in posttranscriptional regulation of mRNA. Evidence has shown that miRNA gene variability might interfere with its function resulting in phenotypic variation and disease susceptibility. A major role in miRNA target recognition is ascribed to complementarity with the miRNA seed region that can be affected by polymorphisms. In the present...
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