Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease.

Abstract excerpt

The expression of at least a third of mammalian genes is post-transcriptionally fine-tuned by approximately 1000 microRNAs (miRNAs), assisted by the RNA silencing machinery, comprising tens of components. Polymorphisms and mutations in the corresponding sequence space (machinery, miRNA precursors and target sites) are likely to make a significant contribution to phenotypic variation, including disease...

Topics

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• Disease
• Gene Expression Regulation
• Genetic Variation
• MicroRNAs
• Phenotype