Heritability of malaria in Africa.

doi:10.1371/journal.pmed.0020340

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Article

Heritability of malaria in Africa.

PLoS medicine - 1 Dec 2005

Mackinnon Margaret J, Mwangi Tabitha W, Snow Robert W, Marsh Kevin, Williams Thomas N

Abstract excerpt

BACKGROUND: While many individual genes have been identified that confer protection against malaria, the overall impact of host genetics on malarial risk remains unknown. METHODS AND FINDINGS: We have used pedigree-based genetic variance component analysis to determine the relative contributions of genetic and other factors to the variability in incidence of malaria and other infectious diseases in two cohorts of...

Topics

Africa
Child
Child, Preschool
Cohort Studies
Female
Genetic Predisposition to Disease
Hemoglobin, Sickle
Humans
Incidence
Kenya
Malaria
Male
Patient Admission
Pedigree
Sri Lanka
alpha-Thalassemia

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Identifiers

PMID: 16259530
DOI: 10.1371/journal.pmed.0020340
PMCID: PMC1277928

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