Article
Alpha4 and beta2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only alpha4 is critical.
Experimental hematology - 1 Apr 2007
Banerjee Ena Ray, Jiang Yi, Henderson William R, Scott Linda M, Papayannopoulou Thalia
Abstract excerpt
OBJECTIVE: Recruitment of effector cell subsets to inflammatory lung, together with airway resident cells responsive to secreted products, play pivotal roles in developing and maintaining asthma. Differential use of adhesion molecules dictates the recruitment patterns of specific cell subsets, yet a clear understanding of the distinctive adhesive molecular pathways guiding them to lung is lacking. To provide...
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