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Article

Nascent endothelium initiates Th2 polarization of asthma.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013

Asosingh Kewal, Cheng Georgiana, Xu Weiling, Savasky Benjamin M, Aronica Mark A, Li Xiaoxia, Erzurum Serpil C

Abstract excerpt

Asthma airway remodeling is linked to Th2 inflammation. Angiogenesis is a consistent feature of airway remodeling, but its contribution to pathophysiology remains unclear. We hypothesized that nascent endothelial cells in newly forming vessels are sufficient to initiate Th2-inflammation. Vascular endothelial (VE)-cadherin is a constitutively expressed endothelial cell adhesion molecule that is exposed in its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23427249
DOI: 10.4049/jimmunol.1202095
PMCID: PMC3608697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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