Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of alpha4-integrin blockade on CD4+ cell-driven late airway responses in the rat.

American journal of respiratory and critical care medicine - 1 Jan 2001

Ramos-Barbón D, Suzuki M, Taha R, Molet S, Issekutz T B, Hamid Q, Martin J G

Abstract excerpt

The blockade of alpha4 integrins with a monoclonal antibody (TA-2) decreases late airway responses (LR) in ovalbumin (OVA)-sensitized and challenged rats. In this study, we used a model of CD4+ cell-driven LR to test the hypothesis that alpha4-integrin blockade involves interference with T-cell a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Antigens, CD
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Interleukin-5

Share to Leukocyte Count

Share to Rats, Inbred BN

Source

Identifiers

PMID: 11208633
DOI: 10.1164/ajrccm.163.1.2001093

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11208633-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of alpha4-integrin blockade on CD4+ cell-driven late airway responses in the rat.PMID 11208633Read ↗

Alpha4 and beta2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only alpha4 is critical.Semantic proximity Read ↗

Role of intercellular adhesion molecule-1 in antigen-induced lung inflammation in brown Norway rats.Semantic proximity Read ↗

T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice.Semantic proximity Read ↗

Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models.Semantic proximity Read ↗

Hypocontractile airway smooth muscle phenotype exhibits enhanced β2 laminin chain expression in lung allergy model.Semantic proximity Read ↗

Analyzing soluble and lung smooth muscle laminin isoform expression in guinea pigs exhibiting various allergic response phenotypes.Semantic proximity Read ↗

Blockade of alpha 4 beta 1-integrin-fibronectin adhesive interactions prevents chronic allograft rejection in sensitized recipients.Semantic proximity Read ↗

Immunopathologic alterations in the bronchi of immunized guinea pigs.Semantic proximity Read ↗

Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation.Semantic proximity Read ↗

Expression of the Human Integrin β 6 Subunit in Alveolar Type II Cells and Bronchiolar Epithelial Cells Reverses Lung Inflammation in β 6 Knockout MiceSemantic proximity Read ↗

Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness.Semantic proximity Read ↗

Anti-inflammatory activity of inhaled mometasone furoate in allergic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.