Article
Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models.
Experimental hematology - 1 Jun 2009
Banerjee Ena Ray, Jiang Yi, Henderson William R, Latchman Yvette, Papayannopoulou Thalia
Abstract excerpt
OBJECTIVE: Chronic asthma is characterized by ongoing recruitment of inflammatory cells and airway hyperresponsiveness leading to structural airway remodeling. Although alpha 4 beta 1 and beta2 integrins regulate leukocyte migration in inflammatory diseases and play decisive roles in acute asthma, their role has not been explored under the chronic asthma setting. To extend our earlier studies with alpha...
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