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Article

c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium.

Molecular and cellular biology - 1 Sept 2005

Bettess Michael D, Dubois Nicole, Murphy Mark J, Dubey Christelle, Roger Catherine, Robine Sylvie, Trumpp Andreas

Abstract excerpt

In self-renewing tissues such as the skin epidermis and the bone marrow, Myc proteins control differentiation of stem cells and proliferation of progenitor cell types. In the epithelium of the small intestine, we show that c-Myc and N-Myc are expressed in a differential manner. Whereas c-Myc is expressed in the proliferating transient-amplifying compartment of the crypts, N-Myc is restricted to the differentiated...

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Identifiers

PMID: 16107730
DOI: 10.1128/MCB.25.17.7868-7878.2005
PMCID: PMC1190312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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