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Article

Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females.

Human reproduction (Oxford, England) - 1 Jun 2007

Zhao Jian, Xiong Dong-Hai, Guo Yan, Yang Tie-Lin, Recker Robert R, Deng Hong-Wen

Abstract excerpt

BACKGROUND: The insulin-like growth factor 1 (IGF1) gene, which plays a crucial role in hypothalamic-pituitary-ovarian hormone-controlled metabolic processes, may influence the onset of menarche. Our study aimed to test association between IGF1 polymorphisms with the variation of age at menarche (AAM) in Caucasian females. METHODS: We recruited a sample of 1048 females from 354 Caucasian nuclear families and...

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Source

Identifiers

PMID: 17376820
DOI: 10.1093/humrep/dem052

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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