Article
Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche.
Nature genetics - 1 Jun 2009
Sulem Patrick, Gudbjartsson Daniel F, Rafnar Thorunn, Holm Hilma, Olafsdottir Elinborg J, Olafsdottir Gudridur H, Jonsson Thorvaldur, Alexandersen Peter, Feenstra Bjarke, Boyd Heather A, Aben Katja K, Verbeek Andre L M, Roeleveld Nel, Jonasdottir Aslaug, Styrkarsdottir Unnur, Steinthorsdottir Valgerdur, Karason Ari, Stacey Simon N, Gudmundsson Julius, Jakobsdottir Margret, Thorleifsson Gudmar, Hardarson Gudmundur, Gulcher Jeffrey, Kong Augustine, Kiemeney Lambertus A, Melbye Mads, Christiansen Claus, Tryggvadottir Laufey, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
Earlier menarche correlates with shorter adult height and higher childhood body fat. We conducted a genome-wide association study of age at menarche (AAM) on 15,297 Icelandic women. Combined analysis with replication sets from Iceland, Denmark and the Netherlands (N = 10,040) yielded a significant association between rs314280[T] on 6q21, near the LIN28B gene, and AAM (effect = 1.2 months later per allele; P = 1.8...
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