Genetic and Clinical Factors Are Associated With Statin-Related Myotoxicity of Moderate Severity: A Case-Control Study.

doi:10.1002/cpt.887

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Genetic and Clinical Factors Are Associated With Statin-Related Myotoxicity of Moderate Severity: A Case-Control Study.

Clinical pharmacology and therapeutics - 1 Jul 2018

Bakar Nur Salwani, Neely Dermot, Avery Peter, Brown Colin, Daly Ann K, Kamali Farhad

Abstract excerpt

We evaluated the contribution of patient-specific clinical and genetic factors to statin-related muscle toxicity (SRM) without a significant creatine kinase elevation (125 cases related to simvastatin or atorvastatin and 481 controls). The association between 12 single nucleotide polymorphisms (SNPs) in nine candidate genes and clinical factors with SRM was evaluated. Of the 12 SNPs genotyped, only rs4149056 in...

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PMID: 28940218
DOI: 10.1002/cpt.887

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