Article
A gene risk score using missense variants in SLCO1B1 is associated with earlier onset statin intolerance.
European heart journal. Cardiovascular pharmacotherapy - 20 Sept 2023
Bigossi Margherita, Maroteau Cyrielle, Dawed Adem Y, Taylor Alasdair, Srinivasan Sundararajan, Melhem Alaa' Lufti, Pearson Ewan R, Pola Roberto, Palmer Colin N A, Siddiqui Moneeza K
Abstract excerpt
BACKGROUND AND AIMS: The efficacy of statin therapy is hindered by intolerance to the therapy, leading to discontinuation. Variants in SLCO1B1, which encodes the hepatic transporter OATB1B1, influence statin pharmacokinetics, resulting in altered plasma concentrations of the drug and its metabolites. Current pharmacogenetic guidelines require sequencing of the SLCO1B1 gene, which is more expensive and less...
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