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Article

Sequence-specific targeting and covalent modification of human genomic DNA.

Nucleic acids research - 1 Sept 1997

Belousov E S, Afonina I A, Podyminogin M A, Gamper H B, Reed M W, Wydro R M, Meyer R B

Abstract excerpt

We compare two techniques which enable selective, nucleotide-specific covalent modification of human genomic DNA, as assayed by quantitative ligation- mediated PCR. In the first, a purine motif triplex-forming oligonucleotide with a terminally appended chlorambucil was shown to label a target guanine residue adjacent to its binding site in 80% efficiency at 0.5 microM. Efficiency was higher in the presence of the...

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Identifiers

PMID: 9254701
DOI: 10.1093/nar/25.17.3440
PMCID: PMC146908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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