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Article

Ultrarapid mutation detection by multiplex, solid-phase chemical cleavage.

Genomics - 10 Dec 1995

Rowley G, Saad S, Giannelli F, Green P M

Abstract excerpt

The chemical cleavage of mismatches in heteroduplexes formed by probe and test DNA detects and locates any sequence change in long DNA segments (approximately 1.8 kb), and its efficiency has been well tested in the analysis of both average (e.g., coagulation factor IX) and large, complex genes (e.g., coagulation factor VIII and dystrophin). In the latter application RT/PCR products allow the examination of all...

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Identifiers

PMID: 8825645
DOI: 10.1006/geno.1995.1279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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