Article
DNA technology for the detection of common genetic variants that predispose to thrombophilia.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Dec 2000
Pecheniuk N M, Walsh T P, Marsh N A
Abstract excerpt
With the identification of common single locus point mutations as risk factors for thrombophilia, many DNA testing methodologies have been described for detecting these variations. Traditionally, functional or immunological testing methods have been used to investigate quantitative anticoagulant deficiencies. However, with the emergence of the genetic variations, factor V Leiden, prothrombin 20210 and, to a...
Topics
- DNA
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Nucleic Acid Amplification Techniques
- Point Mutation
- Thrombophilia