Article
Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours.
Nature genetics - 1 Feb 2000
Rapley E A, Crockford G P, Teare D, Biggs P, Seal S, Barfoot R, Edwards S, Hamoudi R, Heimdal K, Fossâ S D, Tucker K, Donald J, Collins F, Friedlander M, Hogg D, Goss P, Heidenreich A, Ormiston W, Daly P A, Forman D, Oliver T D, Leahy M, Huddart R, Cooper C S, Bodmer J G, Easton D F, Stratton M R, Bishop D T
Abstract excerpt
Testicular germ-cell tumours (TGCT) affect 1 in 500 men and are the most common cancer in males aged 15-40 in Western European populations. The incidence of TGCT has risen dramatically over the last century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, previously diagnosed TGCT (ref. 7) and a family history of the disease. Brothers of men with TGCT...
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