Article
Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.
Cancer cell - 6 Oct 2009
Wang Lizhong, Liu Runhua, Li Weiquan, Chen Chong, Katoh Hiroto, Chen Guo-Yun, McNally Beth, Lin Lin, Zhou Penghui, Zuo Tao, Cooney Kathleen A, Liu Yang, Zheng Pan
Abstract excerpt
Despite clear epidemiological and genetic evidence for X-linked prostate cancer risk, all prostate cancer genes identified are autosomal. Here, we report somatic inactivating mutations and deletion of the X-linked FOXP3 gene residing at Xp11.23 in human prostate cancer. Lineage-specific ablation of FoxP3 in the mouse prostate epithelial cells leads to prostate hyperplasia and prostate intraepithelial neoplasia....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.