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Article

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27.

Genome research - 1 Nov 2005

Kouprina Natalay, Pavlicek Adam, Noskov Vladimir N, Solomon Greg, Otstot John, Isaacs William, Carpten John D, Trent Jeffrey M, Schleutker Joanna, Barrett J Carl, Jurka Jerzy, Larionov Vladimir

Abstract excerpt

Genetic linkage studies indicate that germline variations in a gene or genes on chromosome Xq27-28 are implicated in prostate carcinogenesis. The linkage peak of prostate cancer overlies a region of approximately 750 kb containing five SPANX genes (SPANX-A1, -A2, -B, -C, and -D) encoding sperm proteins associated with the nucleus; their expression was also detected in a variety of cancers. SPANX genes are >95%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16251457
DOI: 10.1101/gr.4212705
PMCID: PMC1310635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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