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Article

Moderate hypermutability of a transgenic lacZ reporter gene in Myc-dependent inflammation-induced plasma cell tumors in mice.

Cancer research - 15 Jan 2004

Felix Klaus, Polack Axel, Pretsch Walter, Jackson Sharon H, Feigenbaum Lionel, Bornkamm Georg-Wilhelm, Janz Siegfried

Abstract excerpt

Mutator phenotypes, a common and largely unexplained attribute of human cancer, might be better understood in mouse tumors containing reporter genes for accurate mutation enumeration and analysis. Previous work on peritoneal plasmacytomas (PCTs) in mice suggested that PCTs have a mutator phenotype caused by Myc-deregulating chromosomal translocations and/or phagocyte-induced mutagenesis due to chronic...

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Source

Identifiers

PMID: 14744766
DOI: 10.1158/0008-5472.can-03-2602

Genes

MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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