Estimation of the upper limit of the mutation rate and mean heterozygous effect of deleterious mutations.

Abstract excerpt

Deng et al. have recently proposed that estimates of an upper limit to the rate of spontaneous mutations and their average heterozygous effect can be obtained from the mean and variance of a given fitness trait in naturally segregating populations, provided that allele frequencies are maintained at the balance between mutation and selection. Using simulations they show that this estimation method generally has...

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