On the three methods for estimating deleterious genomic mutation parameters.

Abstract excerpt

Due to the tremendous cost of the traditional mutation-accumulation approach (the Bateman-Mukai technique), data are rare for deleterious mutation parameters such as genomic mutation rate, selection and dominance coefficients. Two alternative approaches have been developed (the Morton-Charlesworth and Deng-Lynch techniques). Except for the Deng-Lynch method, the statistical properties (bias and sampling variance)...

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