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Article

Population genetics of polymorphism and divergence for diploid selection models with arbitrary dominance.

Genetics - 1 Sept 2004

Williamson Scott, Fledel-Alon Adi, Bustamante Carlos D

Abstract excerpt

We develop a Poisson random-field model of polymorphism and divergence that allows arbitrary dominance relations in a diploid context. This model provides a maximum-likelihood framework for estimating both selection and dominance parameters of new mutations using information on the frequency spectrum of sequence polymorphisms. This is the first DNA sequence-based estimator of the dominance parameter. Our model...

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Identifiers

PMID: 15454557
DOI: 10.1534/genetics.103.024745
PMCID: PMC1448126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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