Article
Less is more: how protein degradation regulates muscle development.
Ernst Schering Foundation symposium proceedings - 1 Jan 2008
Hoppe T
Abstract excerpt
The organization of sarcomeric structures during muscle development involves regulated multistep assembly pathways. The myosin assembly factor UNC-45 functions both as a molecular chaperone and as an Hsp90 co-chaperone for myosin throughout muscle thick-filament formation. Consequently, mutations in unc-45 result in paralyzed worms with severe myofibril disorganization in striated body wall muscles. Our data...
Topics
- Animals
- Genetic Predisposition to Disease
- Humans
- Muscle Development
- Muscle Proteins
- Muscular Diseases