Article
Spontaneous renal tubular hyperplastic and neoplastic lesions in three Sprague-Dawley rats from a 90-day toxicity study.
Toxicologic pathology - 1 Feb 2007
Hall William C, Elder Bruce, Walker Cheryl Lyn, Cai Sheng-Li, Peters David G, Goodman Dawn G, Ulland Borge M, Borzelleca Joseph F
Abstract excerpt
Multiple renal tubular cell adenomas and atypical tubular hyperplasia were diagnosed in 2 high-dose and 1 mid-dose female Sprague-Dawley (Crl:CD (SD)IGS BR) rats from a 90-day toxicity study of an amino acid found in green tea. The tumors were bilateral multicentric adenomas accompanied by atypical foci of renal tubular hyperplasia in both kidneys of the 3 animals. Toxic tubular changes that typically accompany...
Topics
- Adenoma
- Animals
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Glutamates
- Hyperplasia