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Article

A germ-line insertion in the Birt–Hogg–Dubé ( BHD ) gene gives rise to the Nihon rat model of inherited renal cancer

9 Feb 2004

Abstract excerpt

A rat model of hereditary renal carcinoma (RC) was found in a rat colony of the Sprague-Dawley strain in Japan and named the "Nihon" rat. In heterozygotes, RCs, predominantly the clear cell type, develop from early preneoplastic lesions, which began to appear as early as 3 weeks of age, to adenocarcinomas by the age of 6 months. The Nihon rat is an example of a Mendelian dominantly inherited predisposition for...

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PMID: 14769940
DOI: 10.1073/pnas.0308071100

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Source receipt: pubmed, retrieved 7 Sept 2026.

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