Establishment and characterization of renal carcinoma cell lines from a Bhd gene mutant (Nihon) rat.

doi:10.1159/000243768

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Article

Establishment and characterization of renal carcinoma cell lines from a Bhd gene mutant (Nihon) rat.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2009

Matsumoto Izumi, Kouchi Mami, Okimoto Kazuo, Kijima Kazuyasu, Ueda Tadayoshi, Hirayama Youko, Inoue Tadashi, Seki Takaki, Hino Okio

Abstract excerpt

A germline insertion of a single nucleotide in the rat homologue of the human Birt-Hogg-Dubé (BHD) gene gives rise to dominantly inherited renal cell carcinoma (RCC) in the Nihon rat model. In this study, we established 7 lines (NR cell lines NR22, 24, 32, 45, 49, 54 and 64) from an RCC found in a Nihon rat. All cell lines consisted mainly of round or polygonal cells arranged in a cobblestone-like growth pattern....

Topics

Animals
Base Sequence
Carcinoma, Renal Cell
Cell Line, Tumor
Cell Proliferation
DNA Mutational Analysis
Female
Immunohistochemistry
Keratins
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Loss of Heterozygosity

Male

Mice

Mice, Inbred BALB C

Mice, Nude

Microscopy, Electron

Microvilli

Mutation

Source

Open in PubMed

Identifiers

PMID: 19816092
DOI: 10.1159/000243768

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