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Article

c-Myb-dependent inositol 1,4,5-trisphosphate receptor type-1 expression in vascular smooth muscle cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2007

Afroze Talat, Sadi Al Muktafi, Momen M Abdul, Gu Steven, Heximer Scott, Husain Mansoor

Abstract excerpt

OBJECTIVE: The IP3 receptor-1 (IP3R1) mediates Ca2+ signals critical to vascular smooth muscle cell (VSMC) proliferation. The cell cycle-associated transcription factor c-Myb increases Ca2+ at the G1/S transition. Here we show the mechanism through which c-Myb regulates expression of IP3R1. METHODS & RESULTS: Ribonuclease protection confirmed transcriptional start (TS), and qRT-PCR revealed a 6-fold increase in...

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Identifiers

PMID: 17363689
DOI: 10.1161/ATVBAHA.107.142059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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