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Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G<sub>0</sub>/G<sub>1</sub>Arrest via a p53/p21<sup>WAF1/Cip1</sup>-dependent Mechanism

1 Aug 2001

Abstract excerpt

Caveolin-1 is a principal component of caveolae membranes in vivo. Caveolin-1 mRNA and protein expression are lost or reduced during cell transformation by activated oncogenes. Interestingly, the human caveolin-1 gene is localized to a suspected tumor suppressor locus (7q31.1). However, it remains unknown whether caveolin-1 plays any role in regulating cell cycle progression. Here, we directly demonstrate that...

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PMID: 11514613
DOI: 10.1091/mbc.12.8.2229

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