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Article

A novel mechanism of transcriptional repression of p27kip1 through Notch/HRT2 signaling in vascular smooth muscle cells.

Thrombosis and haemostasis - 1 Sept 2006

Havrda Matthew C, Johnson Michael J, O'Neill Christine F, Liaw Lucy

Abstract excerpt

Vascular smooth muscle cell (VSMC) proliferation occurs in vascular obstructive events such as atherosclerosis and restenosis. We previously showed that Notch receptors are induced in smooth muscle cells during vascular remodeling. Our goal was to determine the mechanisms employed by Notch signaling to regulate proliferation. Activation of Notch1 and Notch4 induced the VSMC-selective target genes HRT1 and HRT2,...

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Share to Adenoviridae
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Dose-Response Relationship, Drug

Share to Muscle, Smooth, Vascular

Share to Receptor, Notch1

Share to Repressor Proteins

Source

Identifiers

PMID: 16953280
DOI: 10.1160/TH06-04-0224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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