Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells.

Cancer research - 15 Mar 2007

Hu Wenwei, Feng Zhaohui, Ma Lan, Wagner John, Rice J Jeremy, Stolovitzky Gustavo, Levine Arnold J

Abstract excerpt

Oscillations of both p53 and MDM2 proteins have been observed in cells after exposure to stress. A mathematical model describing these oscillations predicted that oscillations occur only at selected levels of p53 and MDM2 proteins. This model prediction suggests that oscillations will disappear in cells containing high levels of MDM2 as observed with a single nucleotide polymorphism in the MDM2 gene (SNP309). The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Estradiol

Share to Neoplasms

Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 17363597
DOI: 10.1158/0008-5472.CAN-06-2656

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells.PMID 17363597Read ↗

MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner.Semantic proximity Read ↗

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.Semantic proximity Read ↗

A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans.Semantic proximity Read ↗

Stress-specific response of the p53-Mdm2 feedback loop.Semantic proximity Read ↗

MDM2 is a Central Node in the p53 Pathway: 12 Years and CountingSemantic proximity Read ↗

A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.Semantic proximity Read ↗

Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk.Semantic proximity Read ↗

A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells.Semantic proximity Read ↗

Disruption of the p53-Mdm2 complex by Nutlin-3 reveals different cancer cell phenotypes.Semantic proximity Read ↗

A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect.Semantic proximity Read ↗

SNP55, a new functional polymorphism of MDM2-P2 promoter, contributes to allele-specific expression of MDM2 in endometrial cancers.Semantic proximity Read ↗

MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.