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Article

MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner.

Cancer research - 15 May 2006

Bond Gareth L, Hirshfield Kim M, Kirchhoff Tomas, Alexe Gabriella, Bond Elisabeth E, Robins Harlan, Bartel Frank, Taubert Helge, Wuerl Peter, Hait William, Toppmeyer Deborah, Offit Kenneth, Levine Arnold J

Abstract excerpt

The importance of the p53 stress response pathway in the suppression of tumor formation is well documented. In a previous report, a single nucleotide polymorphism (SNP309 T/G) was found in the promoter of the MDM2 gene resulting in higher levels of MDM2 RNA and protein and, consequently, in the a...

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Source

Identifiers

PMID: 16707433
DOI: 10.1158/0008-5472.CAN-06-0180

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16707433-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner.PMID 16707433Read ↗

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.Semantic proximity Read ↗

A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans.Semantic proximity Read ↗

MDM2 SNP309 accelerates colorectal tumour formation in womenSemantic proximity Read ↗

MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.Semantic proximity Read ↗

Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk.Semantic proximity Read ↗

A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.Semantic proximity Read ↗

The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians.Semantic proximity Read ↗

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SNP285C modulates oestrogen receptor/Sp1 binding to the MDM2 promoter and reduces the risk of endometrial but not prostatic cancer.Semantic proximity Read ↗

A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells.Semantic proximity Read ↗

MDM2 promoter SNP285 and SNP309; phylogeny and impact on cancer risk.Semantic proximity Read ↗

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