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Article

Integrin alpha v beta 3 controls activity and oncogenic potential of primed c-Src.

Cancer research - 15 Mar 2007

Huveneers Stephan, van den Bout Iman, Sonneveld Petra, Sancho Ana, Sonnenberg Arnoud, Danen Erik H J

Abstract excerpt

Increased activity of the proto-oncogene c-Src and elevated levels of integrin alpha(v)beta(3) are found in melanomas and multiple carcinomas. Regulation of c-Src involves "priming" through disruption of intramolecular interactions followed by "activation" through phosphorylation in the kinase domain. Interactions with overexpressed receptor tyrosine kinases or mutations in the SRC gene can induce priming of...

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Source

Identifiers

PMID: 17363590
DOI: 10.1158/0008-5472.CAN-06-3654

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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