Article
VEGF-integrin interplay controls tumor growth and vascularization.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 2005
De Sarmishtha, Razorenova Olga, McCabe Noel Patrick, O'Toole Timothy, Qin Jun, Byzova Tatiana V
Abstract excerpt
Cross-talk between the major angiogenic growth factor, VEGF, and integrin cell adhesion receptors has emerged recently as a critical factor in the regulation of angiogenesis and tumor development. However, the molecular mechanisms and consequences of this intercommunication remain unclear. Here, we define a mechanism whereby integrin alpha v beta3, through activation, clustering, and signaling by means of p66 Shc...
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