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Article

Long-term hormonal promotion overcomes genetic resistance to mammary cancer.

Steroids - 1 Jan 2011

Rajkumar Lakshmanaswamy, Arumugam Arunkumar, Elsayed Ahmed, Schecter Scott, Kotkowski Eithan, Castillo Ruth, de la Torre Aleyah, Hernandez Cecilio

Abstract excerpt

It is well known that ovarian steroids estradiol and progesterone play a vital role in the development of mammary cancer. Here, using the genetically highly resistant Copenhagen rats we demonstrate that sustained exogenous treatment with estradiol and progesterone overcomes genetic resistance to mammary cancer. It has been demonstrated that Copenhagen rats develop preneoplastic lesions upon exposure to...

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Source

Identifiers

PMID: 20732338
DOI: 10.1016/j.steroids.2010.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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