Article
Ubiquitination of alpha-synuclein.
Biochemistry - 11 Jan 2005
Nonaka Takashi, Iwatsubo Takeshi, Hasegawa Masato
Abstract excerpt
Filamentous alpha-synuclein depositions are the defining hallmarks of a subset of neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. We previously reported that alpha-synuclein in those brains are extensively phosphorylated at Ser129 [Fujiwara et al. (2002) Nat. Cell Biol. 4, 160-164] and also partially ubiquitinated [Hasegawa et al. (2002) J....
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