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Article

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.

Molecular and cellular biology - 1 Sept 2002

Hirao Atsushi, Cheung Alison, Duncan Gordon, Girard Pierre-Marie, Elia Andrew J, Wakeham Andrew, Okada Hitoshi, Sarkissian Talin, Wong Jorge A, Sakai Takashi, De Stanchina Elisa, Bristow Robert G, Suda Toshio, Lowe Scott W, Jeggo Penny A, Elledge Stephen J, Mak Tak W

Abstract excerpt

In response to ionizing radiation (IR), the tumor suppressor p53 is stabilized and promotes either cell cycle arrest or apoptosis. Chk2 activated by IR contributes to this stabilization, possibly by direct phosphorylation. Like p53, Chk2 is mutated in patients with Li-Fraumeni syndrome. Since the...

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Source

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Identifiers

PMID: 12192050
DOI: 10.1128/MCB.22.18.6521-6532.2002
PMCID: PMC135625

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12192050-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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