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Article

<i>Drosophila</i> Chk2 is required for DNA damage‐mediated cell cycle arrest and apoptosis

7 Nov 2001

Abstract excerpt

Chk2 is a major target of ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR). Germline mutations in Chk2 have been identified in a subset of patients with Li-Fraumeni syndrome, suggesting that Chk2 is a tumor suppressor gene. To investigate the role of Chk2 in multicellular organisms, a Drosophila chk2 (Dmchk2) mutant was generated. Dmchk2 mutants are viable but show defects in maintaining genome...

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Identifiers

PMID: 11728459
DOI: 10.1016/s0014-5793(01)03103-9

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