Article
Serotonin transporter gene polymorphism (5-HTTLPR) in patients with oral lichen planus.
Archives of oral biology - 1 Sept 2007
Perdigão Paôlla Freitas, Guimarães André Luiz Sena, Victoria Junia Maria Netto, Xavier Guilherme Machado, Romano-Silva Marco Aurélio, Gomez Ricardo Santiago
Abstract excerpt
BACKGROUND: Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter (5-HTT) may be involved in psychiatric alterations. Recent findings have demonstrated that depression and stress are influenced by polymorphism of the promoter region of 5-HTT (5-HTTLPR) and that the short allele (S) is associated with reduced transcriptional efficiency resulting in reduced serotonin...
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