Article
The impact of estradiol on bone mineral density is modulated by the specific estrogen receptor-alpha cofactor retinoblastoma-interacting zinc finger protein-1 insertion/deletion polymorphism.
The Journal of clinical endocrinology and metabolism - 1 Jun 2007
Grundberg Elin, Akesson Kristina, Kindmark Andreas, Gerdhem Paul, Holmberg Anna, Mellström Dan, Ljunggren Osten, Orwoll Eric, Mallmin Hans, Ohlsson Claes, Brändström Helena
Abstract excerpt
CONTEXT: Estrogens regulate bone mass by binding to the estrogen receptor (ER)-alpha as well as ER-beta. The specific ERalpha cofactor retinoblastoma-interacting zinc finger protein (RIZ)-1 enhances ERalpha function in the presence of estrogen. OBJECTIVE: The objective of the study was to determine whether a RIZ P704 insertion (+)/deletion (-) (indel) polymorphism modulates the impact of estradiol on bone mineral...
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