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Estrogen Receptor Gene Polymorphisms and the Genetics of Osteoporosis: A HuGE Review

3 Feb 2005

Abstract excerpt

Osteoporosis (OMIM166710) is a common skeletal disorder characterized by low bone mass and microarchitectural deterioration of bone tissue with increased susceptibility to fracture. Osteoporosis has a complex etiology and is considered a multifactorial polygenic disease in which genetic determinants are modulated by hormonal, environmental, and nutritional factors. Estrogens are known to play an important role in...

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PMID: 15692074
DOI: 10.1093/aje/kwi055

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