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Article

Clinicopathologic features of frontotemporal dementia with progranulin sequence variation.

Neurology - 13 Mar 2007

Spina S, Murrell J R, Huey E D, Wassermann E M, Pietrini P, Baraibar M A, Barbeito A G, Troncoso J C, Vidal R, Ghetti B, Grafman J

Abstract excerpt

BACKGROUND: Frontotemporal lobar degeneration with ubiquitin-immunoreactive (ub-ir) inclusions (FTLD-U) has been associated with frontotemporal dementia (FTD) and ALS. Recently, mutations in Progranulin (PGRN), predicted to cause premature truncation of the PGRN coding sequence, were found in patients with inherited FTLD-U and ub-ir neuronal intranuclear inclusions (NII). OBJECTIVE: To describe clinical,...

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Identifiers

PMID: 17202431
DOI: 10.1212/01.wnl.0000254460.31273.2d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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