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Article

Endocrine expression of the active form of TGF-beta1 in the TGF-beta1 null mice fails to ameliorate lethal phenotype.

Cytokine - 7 Apr 2002

Longenecker Glenn, Thyagarajan Tamizchelvi, Nagineni Chandrasekharam N, Flanders Kathleen C, Factor Valentina, Miller Georgina, Ward Jerrold M, Nalca Aysegul, Rangnekar Vivek M, Thorgeirsson Snorri, Kulkarni Ashok B

Abstract excerpt

TGF-beta1 null mice die by 3 to 4 weeks of age due to a severe autoimmune-mediated multifocal inflammation resulting in multi-organ failure. To assess the therapeutic potential of circulating levels of active TGF-beta1, we generated mice with endocrine expression of active TGF-beta1 on a TGF-beta1 null background (TGF-beta1 (-/-/TG)) by crossing TGF-beta1(+/-) mice with transgenic mice (TG) that express...

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Identifiers

PMID: 12090759
DOI: 10.1006/cyto.2002.1025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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