TGFbeta1 and TGFbeta3 are partially redundant effectors in brain vascular morphogenesis.

Abstract excerpt

Gene deletion experiments have shown that the three TGFbeta isoforms regulate distinct developmental processes. Recent work by our group and others showed that the integrins alphavbeta6 and alphavbeta8 activate latent forms of TGFbeta1 and TGFbeta3. This raises the possibility that TGFbeta1 and TGFbeta3 act redundantly in developmental processes where both isoforms are expressed and activation is by integrins. To...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Deletion
• Share to Gene Expression Regulation, Developmental