Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Evaluation of ABCB1 (P-Glycoprotein) Polymorphisms: High-Speed Screening and Structure-Activity Relationship Analyses

1 Jan 2004

Abstract excerpt

Evidence is accumulating to strongly suggest that drug transporters are one of the determinant factors governing the pharmacokinetic profile of drugs. Effort has been made to identify genetic variation in drug transporter genes. In particular, genetic variations of the human ABCB1 (MDR1) gene have been most extensively studied. Hitherto more than fifty single nucleotide polymorphisms (SNPs) and insertion/deletion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to HIV/AIDS drug development and treatment
Share to Pharmacological Effects and Toxicity Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15499164
DOI: 10.2133/dmpk.19.1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Evaluation of ABCB1 (P-Glycoprotein) Polymorphisms: High-Speed Screening and Structure-Activity Relationship AnalysesPMID 15499164Read ↗

Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.Semantic proximity Read ↗

Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1).Semantic proximity Read ↗

An update on ABCB1 pharmacogenetics: insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics.Semantic proximity Read ↗

In Silico Screening and Analysis of SNPs in Human ABCB1 (MDR1) GeneSemantic proximity Read ↗

Emerging new technologies in Pharmacogenomics: rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1).Semantic proximity Read ↗

Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.Semantic proximity Read ↗

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)Semantic proximity Read ↗

Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).Semantic proximity Read ↗

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.Semantic proximity Read ↗

The effect of ABCB1 polymorphisms on the outcome of breast cancer treatmentSemantic proximity Read ↗

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.Semantic proximity Read ↗

ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.