Characterization of p21Ras-mediated apoptosis induced by protein kinase C inhibition and application to human tumor cell lines.

doi:10.1002/jcp.10409

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Article

Characterization of p21Ras-mediated apoptosis induced by protein kinase C inhibition and application to human tumor cell lines.

Journal of cellular physiology - 1 Feb 2004

Liou James S, Chen James S, Faller Douglas V

Abstract excerpt

Suppression of PKC activity can selectively induce apoptosis in cells expressing a constitutively activated p21Ras protein. We demonstrate that continued expression of p21Ras activity is required in PKC-mediated apoptosis because farnesyltransferase inhibitors abrogated the loss of viability in p21Ras-transformed cells occurring following PKC inhibition. Studies utilizing gene transfer or viral vectors...

Topics

Animals
Apoptosis
CHO Cells
Cell Line, Tumor
Cricetinae
Cricetulus
Enzyme Inhibitors
Genes, ras
Glyceryl Ethers
Humans
Jurkat Cells
Membrane Potentials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mitochondria

Mutation

NIH 3T3 Cells

Protein Kinase C

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed

Identifiers

PMID: 14603530
DOI: 10.1002/jcp.10409

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14603530-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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