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Article

Crosstalk between tumor suppressors p53 and PKCδ: Execution of the intrinsic apoptotic pathways.

Cancer letters - 28 Jul 2016

Dashzeveg Nurmaa, Yoshida Kiyotsugu

Abstract excerpt

p53 and PKCδ are tumor suppressors that execute apoptotic mechanisms in response to various cellular stresses. p53 is a transcription factor that is frequently mutated in human cancers; it regulates apoptosis in transcription-dependent and -independent ways in response to genotoxic stresses. PKCδ is a serine/threonine protein kinase and mutated in human cancers. Available evidence shows that PKCδ activates p53 by...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Potential, Mitochondrial

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Source

Identifiers

PMID: 27130668
DOI: 10.1016/j.canlet.2016.04.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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