Article
The protein network of HIV budding.
Cell - 19 Sept 2003
von Schwedler Uta K, Stuchell Melissa, Müller Barbara, Ward Diane M, Chung Hyo-Young, Morita Eiji, Wang Hubert E, Davis Thaylon, He Gong-Ping, Cimbora Daniel M, Scott Anna, Kräusslich Hans-Georg, Kaplan Jerry, Morham Scott G, Sundquist Wesley I
Abstract excerpt
HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into multivesicular bodies (MVB). To test whether other proteins involved in MVB biogenesis (the class E proteins) also participate in HIV release, we identified 22 candidate human class E proteins. These proteins were connected into a coherent network by 43 different protein-protein interactions, with AIP1 playing a key...
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