Article
Immunogenetic control of antibody responsiveness in a malaria endemic area.
Human immunology - 1 Mar 2007
Carpenter Danielle, Abushama Hind, Bereczky Sándor, Färnert Anna, Rooth Ingegerd, Troye-Blomberg Marita, Quinnell Rupert J, Shaw Marie-Anne
Abstract excerpt
This study builds upon the established genetic control of antimalarial immune responses and prior association studies by using a family-based approach, transmission disequilibrium testing, to identify immune response genes that influence antibody responses to Plasmodium falciparum infection in an endemic Tanzanian population. Candidate polymorphisms are within the interleukin-1 (IL-1) gene cluster, the IL-10...
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