Decreased fidelity of DNA polymerases and decreased DNA excision repair in aging mice: effects of caloric restriction.

doi:10.1016/0006-291x(92)91790-w

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Article

Decreased fidelity of DNA polymerases and decreased DNA excision repair in aging mice: effects of caloric restriction.

Biochemical and biophysical research communications - 31 Jan 1992

Srivastava V K, Busbee D L

Abstract excerpt

Hepatic DNA polymerases from calorie restricted and ad libitum 26 month old C57BL/6 mice showed a decline in fidelity of nucleotide incorporation compared with weanling animals. Both alpha and beta polymerases from calorie restricted aged mice exhibited a higher level of fidelity than polymerases...

Topics

Aging
Animals
Cells, Cultured
DNA Polymerase I
DNA Polymerase II
DNA Repair
DNA Replication
Energy Intake
Exodeoxyribonuclease V
Exodeoxyribonucleases
Female
Liver
Mice
Mice, Inbred C57BL
Mutation

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