Article
Decreased fidelity of DNA polymerases and decreased DNA excision repair in aging mice: effects of caloric restriction.
Biochemical and biophysical research communications - 31 Jan 1992
Srivastava V K, Busbee D L
Abstract excerpt
Hepatic DNA polymerases from calorie restricted and ad libitum 26 month old C57BL/6 mice showed a decline in fidelity of nucleotide incorporation compared with weanling animals. Both alpha and beta polymerases from calorie restricted aged mice exhibited a higher level of fidelity than polymerases from ad libitum aged mice. UV-initiated unscheduled DNA synthesis was significantly higher in hepatocytes from...
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